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anaplastic thyroid cancer : ウィキペディア英語版 | anaplastic thyroid cancer
Anaplastic thyroid cancer (ATC) is a form of thyroid cancer which has a very poor prognosis due to its aggressive behavior and resistance to cancer treatments. ==Presentation== Anaplastic tumors have a high mitotic rate and lymphovascular invasion.〔Hu MI, Vassilopoulou-Sellin R, Lustig R, Lamont JP. ("Thyroid and Parathyroid Cancers" ) in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) (Cancer Management: A Multidisciplinary Approach ). 11 ed. 2008.〕 It rapidly invades surrounding tissues (such as the trachea). The presence of regional lymphadenopathy in older patients in whom needle aspiration biopsy reveals characteristic vesicular appearance of the nuclei would support a diagnosis of anaplastic carcinoma. It is always considered as stage IV.〔Harrison's Principles of Internal Medicine, 18th edition, p.2934〕
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